Significance Of Clodronate Liposome In Medicine ? Hot Article Depot

There have been major improvements regarding therapeutic treatments for various human medical diseases. This includes gene therapy, several anti cancer treatments and now clodronate liposome. Indeed, the latter have showed promising results that might help on the treatment of various autoimmune diseases, prevention of transplantation rejection and most importantly, cancer.

Macrophage is considered to be one of the important components of the immune system. It has two important functions and that includes the regulation of non phagocytic cell and it basically activates the natural immune response. In addition to that, macrophages has a significant role during immunity and immune responses. Macrophages are also responsible on the homoeostasis of the body through ingestion and digestion of microorganism.

Clodronate liposome is a type of component whose mechanism of action focuses on the suppression of the immune system. As what is popularly known, the immune system is important to the body as this is what defends the body from certain bacterial and viral infection. That is true of course, however the immune system could also be a culprit to the human?s body.

In normal circumstances, this process makes the body cope up with simple diseases such as colds or cough, thus the term healthy immune system. However, a damage to the immune system could make it passive or overly active. An overly active immune system will result to autoimmune diseases, wherein your own immune cells are attacking your own cells causing several medical disorders.

Clodronate or also known as clodronic acid or clodronate disodium is a bisphosphonate that depletes macrophage hence reducing phagocytosis and suppresses the immune system. Liposomes on the other hand are artificially made lipid vesicles that are mostly used to encapsulate or carry strong hydrophilic substance in aqueous solution, for example clodronate.

During normal circumstances, such process is not harmful at all. Instead, it actually protects the body from infestation. But as mentioned, certain damages to the immune system could lead to serious autoimmune medical conditions. Transplant rejection is one of the effects of immune response. This time as the newly harvested organ is placed on the transplant patient, certain cells may trigger the immune system to attack the organ cells massively thus resulting to rejection.

After injection of the liposome containing the active component, macrophages will identify such component as foreign hence activating phagocytosis. As soon as the liposome is engulfed by the phagocyte, it will release the active component, clodronate inside then inducing apoptosis. Apoptosis is a process that cause cell death.

However this time, the cell being attacked is the macrophage. To correlate it with the autoimmune diseases, damage to the macrophage effectively suppresses the immune system making it a promising therapeutic treatment to patients with autoimmune disease and to prevent rejection to people who had just undergone transplantation. Suppression of the immune system is significant towards treatment or slowing down disease progression in autoimmune diseases.

During cancer, clodronate liposome helps by improving anti tumor effects of anti tumor drugs and effectively increase plasma absorption. This phenomenon may not be able to cure the disease itself, however the disease will be properly managed by then. There?s no doubt that such component holds a great relevance in medicine, especially disease treatment. Certain countries such as Australia, Canada, Italy and the United Kingdom has allowed such treatment to be used by humans.

Find clodronate liposome by touring our web pages at www.clodrosome.com today. To watch our educational videos or to learn more about the routes of administration, check out the links at http://www.clodrosome.com now.

Source: http://hotarticledepot.com/significance-of-clodronate-liposome-in-medicine/

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